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The structure of the most studied DNA fragment changes under the influence of ions: a new packing of d(CGCGAATTCGCG)
Author(s) -
Liu Jie,
Malinina Lucy,
Huynh-Dinh Tam,
Subirana Juan A
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01295-2
Subject(s) - oligonucleotide , chemistry , dna , guanine , crystallography , molecule , stereochemistry , biochemistry , nucleotide , gene , organic chemistry
The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA‐drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca 2+ . The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers.