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Modulation of agonist and antagonist interactions in serotonin 1A receptors by alcohols
Author(s) -
Harikumar K.G,
Chattopadhyay Amitabha
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01284-8
Subject(s) - agonist , chemistry , endogenous agonist , receptor , antagonist , 5 ht receptor , serotonin , serotonergic , pharmacology , biochemistry , biophysics , biology , dopamine receptor d1
The serotonin type 1A (5‐HT 1A ) receptors are members of a superfamily of seven transmembrane domain receptors that couple to GTP binding regulatory proteins (G‐proteins). Serotonergic signalling has been shown to play an important role in alcohol tolerance and dependence. We have studied the effects of alcohols on ligand (agonist and antagonist) binding to bovine hippocampal 5‐HT 1A receptor in native as well as solubilized membranes. Our results show that alcohols inhibit the specific binding of the agonist OH‐DPAT and the antagonist p ‐MPPF to 5‐HT 1A receptors in a concentration‐dependent manner.