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Distribution of orexin receptor mRNA in the rat brain
Author(s) -
Trivedi Prashant,
Yu Hong,
MacNeil Douglas J,
Van der Ploeg L.H.T,
Guan Xiao-Ming
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01266-6
Subject(s) - dorsal raphe nucleus , nucleus accumbens , hypothalamus , orexin , nucleus , medicine , locus coeruleus , endocrinology , orexin receptor , receptor , lateral hypothalamus , chemistry , messenger rna , hippocampal formation , biology , central nervous system , neuroscience , neuropeptide , serotonin , gene , biochemistry , serotonergic
The expression pattern of mRNA encoding two orexin receptors (OX 1 R and OX 2 R) in the rat brain was examined. OX 1 R and OX 2 R exhibited marked differential distribution. Within the hypothalamus, OX 1 R mRNA is most abundant in the ventromedial hypothalamic nucleus whereas OX 2 R is predominantly expressed in the paraventricular nucleus. High levels of OX 1 R mRNA were also detected in tenia tecta, the hippocampal formation, dorsal raphe, and locus coeruleus. OX 2 R mRNA is mainly expressed in cerebral cortex, nucleus accumbens, subthalamic and paraventricular thalamic nuclei, anterior pretectal nucleus. The presence of orexin receptor mRNA in the hypothalamus is in support of its proposed role in feeding regulation. Broad central distribution of orexin receptors may indicate additional functions for orexins.