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Carcinoembryonic antigen‐related cell‐cell adhesion molecule C‐CAM is greatly increased in serum and urine of rats with liver diseases
Author(s) -
Lucka Lothar,
Sel Serdar,
Danker Kerstin,
Horstkorte Rüdiger,
Reutter Werner
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01265-4
Subject(s) - carcinoembryonic antigen , urine , cell , cell adhesion molecule , antigen , liver cell , hepatitis , cell membrane , chemistry , medicine , cell adhesion , endocrinology , biochemistry , immunology , cancer
C‐CAM (rat cell CAM/human CD66a) is ubiquitous and multifunctional. It is involved in intercellular adhesion, signal transduction and cell growth inhibition. Structurally, it is related to the carcinoembryonic antigen. In the present study serum, bile and urine of rats with liver diseases were analyzed for the presence of cell CAM. After bile duct ligation and during galactosamine (GalN) hepatitis we found that large amounts of liver membrane‐bound C‐CAM are secreted or shed into blood. The serum level of another liver membrane‐bound protein, LI‐cadherin, is not increased. It was shown that C‐CAM is also present in bile fluid, and for the first time that C‐CAM is present in the urine of rats with liver diseases. A particularly high concentration was measured in the urine of rats suffering from GalN hepatitis.