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Molecular anatomy of the human glucose 6‐phosphate dehydrogenase core promoter
Author(s) -
Franzè Annamaria,
Ferrante Maria Immacolata,
Fusco Francesca,
Santoro Antonietta,
Sanzari Emma,
Martini Giuseppe,
Ursini Matilde Valeria
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01259-9
Subject(s) - glucose 6 phosphate dehydrogenase , dehydrogenase , promoter , gene , biology , microbiology and biotechnology , biochemistry , gene expression , enzyme
The gene encoding glucose 6‐phosphate dehydrogenase (G6PD), which plays a pivotal role in cell defense against oxidative stress, is ubiquitously expressed at widely different levels in various tissues; moreover, G6PD expression is regulated by a number of stimuli. In this study we have analyzed the molecular anatomy of the G6PD core promoter. Our results indicate that the G6PD promoter is more complex than previously assumed; G6PD expression is under the control of several elements that are all required for correct promoter functioning and, furthermore, a still unidentified mammalian specific factor is needed.