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Expression of specific white adipose tissue genes in denervation‐induced skeletal muscle fatty degeneration
Author(s) -
Dulor Jean-Paul,
Cambon Brigitte,
Vigneron Pierre,
Reyne Yves,
Nouguès Jean,
Casteilla Louis,
Bacou Francis
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01216-2
Subject(s) - denervation , adipose tissue , white adipose tissue , connective tissue , skeletal muscle , biology , endocrinology , atrophy , degeneration (medical) , medicine , pathology , genetics
Denervation of skeletal muscle results in rapid atrophy with loss of contractile mass and/or progressive degeneration of muscle fibers which are replaced to a greater or lesser degree by connective and fatty tissues. In this study, we show that denervated rabbit muscles are transformed into a white adipose tissue, depending on their fiber types. This tissue does express LPL, G3PDH and particularly the ob gene, a white adipose tissue‐specific marker, and does not express the brown adipose tissue molecular marker UCP1 mRNA.