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Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model
Author(s) -
Sanchı́s Daniel,
Busquets Sı́lvia,
Alvarez Belén,
Ricquier Daniel,
López-Soriano Francisco J,
Argilés Josep M
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01178-8
Subject(s) - ucp3 , cachexia , skeletal muscle , anorexia , messenger rna , uncoupling protein , endocrinology , medicine , biology , gene expression , gene , cancer , cancer research , genetics , adipose tissue , brown adipose tissue
Rats bearing the Yoshida AH‐130 ascites hepatoma showed an increased expression of both uncoupling protein‐2 (UCP2) (194%) and UCP3 (189%) mRNA levels in skeletal muscle 7 days after tumour inoculation. Interestingly, an even greater increase was observed in mRNA for both UCP2 (278%) and UCP3 (797%) in the pair‐fed animals, suggesting that the increase in gene expression was the result of the anorexia associated with tumour burden. The results constitute the first report of UCP2 and UCP3 gene expression during cancer cachexia and agree to their possible role in the increase of energy expenditure associated with tumour growth.