Premium
Diacylglycerol pyrophosphate: a novel metabolite in the Trypanosoma cruzi phosphatidic acid metabolism 1
Author(s) -
Marchesini Norma,
Santander Verónica,
Machado-Domenech Estela
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01169-7
Subject(s) - phosphatidic acid , phosphatidate , diacylglycerol kinase , pyrophosphate , trypanosoma cruzi , biochemistry , phospholipase d , metabolite , biology , chemistry , metabolism , second messenger system , phosphatase , enzyme , protein kinase c , phospholipid , membrane , parasite hosting , world wide web , computer science
This work provides evidence that phosphatidic acid (PA) is metabolized to diacylglycerol pyrophosphate (DGPP) in Trypanosoma cruzi . Also the presence of the enzymatic activities involved in its regulation, phosphatidate kinase (PA‐k) and phosphatidate phosphatase, is demonstrated. The increase of DGPP levels in T. cruzi epimastigotes or in its membrane fraction after exogenous PA addition or phospholipase (PLD) pre‐treatment suggests that PA‐k may be involved in the regulation of PA levels after its stimulation.