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Antioxidant properties of ticlopidine on human low density lipoprotein oxidation
Author(s) -
Lapenna Domenico,
de Gioia Sergio,
Ciofani Giuliano,
Bruno Cristiana,
Porreca Ettore,
Pierdomenico Sante D,
Cuccurullo Franco
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01166-1
Subject(s) - ticlopidine , chemistry , antioxidant , radical , low density lipoprotein , in vivo , aspirin , pro oxidant , lipoprotein , biochemistry , pharmacology , cholesterol , medicine , clopidogrel , biology , microbiology and biotechnology
We found that ticlopidine, at therapeutically relevant concentrations (2.5–10 μM), but not aspirin nor salicylate, significantly counteracted copper‐driven human LDL oxidation. Ticlopidine, at 5 and 10 μM, was also antioxidant on peroxyl radical‐induced LDL oxidation; yet it was ineffectual on thiol and ascorbate oxidation mediated by peroxyl radicals themselves, suggesting that drug antioxidant capacity is somehow related to the lipoprotein nature of the oxidizable substrate, but not to radical scavenging. The drug could not indeed react with the stable free radical 1,1‐diphenyl‐2‐pycrylhydrazyl, nor had apparent metal complexing‐inactivating activity. Thus, ticlopidine has antioxidant effects on LDL oxidation, which, together with its anti‐platelet activity, could confer peculiar antiatherogenic properties to the drug in vivo.