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Different response to inflammation of the multiple mRNAs of rat N ‐acetylglucosaminyltransferase I with variable 5′‐untranslated sequences 1
Author(s) -
Fukada Takashi,
Kioka Noriyuki,
Nishiu Jun,
Sakata Shohei,
Yamada Masayasu,
Komano Tohru
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01136-3
Subject(s) - messenger rna , inflammation , untranslated region , microbiology and biotechnology , biology , three prime untranslated region , gene expression , chemistry , gene , biochemistry , immunology
We found that there are at least five subclasses of N ‐acetylglucosaminyltransferase I (GnT‐I; EC 2.4.1.101) mRNA with different 5′‐untranslated regions in rat brain. These five subclasses were also expressed in many tissues with distinct tissue‐specific patterns. Moreover, they were regulated differently in response to acute‐phase inflammation. The expression of the most abundant subclass of GnT‐I mRNA in rat liver decreased 2.5‐fold in response to inflammation, concomitantly with a significant decrease in the total amount of GnT‐I mRNA. In contrast, one of the minor subclasses of GnT‐I mRNA was induced 10‐fold by inflammation.