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Differential activity of a variant form of the human Id‐1 protein generated by alternative splicing
Author(s) -
Tamura Yutaka,
Sugimoto Masataka,
Ohnishi Kotaro,
Sakai Toshiyuki,
Hara Eiji
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01117-x
Subject(s) - basic helix loop helix , alternative splicing , rna splicing , biology , helix (gastropod) , transcription (linguistics) , genetics , transcription factor , microbiology and biotechnology , dna binding protein , gene , rna , exon , ecology , linguistics , philosophy , snail
Members of the Id family of helix‐loop‐helix proteins are ubiquitously expressed and dimerize with members of the class A and class B basic helix‐loop‐helix proteins. Due to the absence of a basic region, Id proteins act as dominant‐negative antagonists of basic helix‐loop‐helix transcription factors, which regulate cell growth and differentiation in diverse cell types. Recent findings suggest that the functions of Id proteins are well regulated at both the transcriptional level and the post‐transcriptional level. We show here that the alternative splicing variant of human Id‐1 protein possesses a different binding specificity for basic helix‐loop‐helix transcription factors and is expressed in a cell cycle‐dependent manner. Therefore, alternative splicing of Id‐1 could provide a post‐transcriptional mechanism to regulate Id‐1 function.