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Intestinal lactase‐phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro‐LPH maturation
Author(s) -
Zecca Laura,
Mesonero José E,
Stutz Alfred,
Poirée Jean-Claude,
Giudicelli Jean,
Cursio Raffaele,
Gloor Sergio M,
Semenza Giorgio
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01076-x
Subject(s) - phlorizin , hydrolase , lactase , brush border , biochemistry , chemistry , trypsin , enzyme , biology , endocrinology , glucose transporter , insulin , vesicle , membrane
The proteolytic processing of pro‐lactase‐phlorizin hydrolase by (rat) enterocytes stops two amino acid residues short of the N‐terminus of ‘mature’ final, brush border lactase‐phlorizin hydrolase. Only these two amino acid residues are removed by luminal pancreatic protease(s), probably trypsin.