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Age‐related increased susceptibility of high‐density lipoproteins (HDL) to in vitro oxidation induced by γ‐radiolysis of water
Author(s) -
Khalil Abdelouahed,
Jay-Gerin Jean-Paul,
Fülöp Tamàs
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01058-8
Subject(s) - chemistry , radiolysis , radical , in vitro , medicine , endocrinology , antioxidant , vitamin e , thiobarbituric acid , biochemistry , population , cholesterol , lipid peroxidation , biology , environmental health
In the present study, we investigated the age‐related susceptibility of high‐density lipoproteins (HDL) to oxidation. HDL were obtained from healthy, normolipidemic young, middle‐aged and elderly subjects. Oxidation of HDL was induced in vitro by oxygen free radicals generated by water γ‐radiolysis, and followed by the decrease of endogenous vitamin E and the formation of conjugated dienes and thiobarbituric acid‐reactive substances, as well as the alterations of apolipoproteins A‐I/A‐II. The resistance of HDL to oxidation, evaluated by the length of the lag phase, decreased with aging. This increased oxidizability of HDL with aging could have a dramatic impact on the development of atherosclerosis in the elderly population.