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Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae
Author(s) -
Garcia-Ranea Juan Antonio,
Valencia Alfonso
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00967-3
Subject(s) - saccharomyces cerevisiae , superfamily , diversification (marketing strategy) , distribution (mathematics) , genetics , biology , computational biology , yeast , gene , business , mathematics , mathematical analysis , marketing
The recent availability of the full Saccharomyces cerevisiae genome sequence offers a first opportunity to analyze the composition, function and evolution of GTPases in the ras‐p21 superfamily. This superfamily in yeast is composed of 29 proteins divided into five families: ras with four sequences implicated in cell signalling; rho, six genes related to the cell shape machinery; ypt‐rab, ten proteins with different roles in intracellular trafficking; arf‐sar, seven proteins related to vesicular trafficking in secretory pathways; and ran, two proteins acting as components of the nuclear transport system. The superfamily covers a wide range of cellular functions from signalling to intracellular trafficking, while conserving the structural framework and a common mechanism of GTP hydrolysis.