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The GalR2 galanin receptor mediates galanin‐induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation
Author(s) -
Wang Suke,
Ghibaudi Lorraine,
Hashemi Tanaz,
He Chaogang,
Strader Catherine,
Bayne Marvin,
Davis Harry,
Hwa Joyce J
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00957-0
Subject(s) - galanin , galanin receptor , receptor , neuropeptide , endocrinology , medicine , biology , contraction (grammar) , biochemistry
The neuropeptide galanin mediates a diverse array of physiological functions through activation of specific receptors. Roles of the three recently cloned galanin receptors (GalRs) in rat intestinal contraction and food intake were examined using GalR‐selective ligands and the results were compared with the pharmacological profiles of defined GalRs. The action profile of these ligands in jejunal contraction resembled only that of GalR2 and only a high level of GalR2 mRNA was detected in the tissue, supporting GalR2 as the receptor mediating jejunal contraction. The action profile for food intake in rats excluded GalR2, GalR3 and the putative pituitary galanin receptor as the ‘feeding receptor’, suggesting that either GalR1 or an unidentified GalR is responsible for mediating this function.