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The relationship between synonymous codon usage and protein structure
Author(s) -
Tao Xie,
Dafu Ding
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00955-7
Subject(s) - codon usage bias , synonymous substitution , biology , silent mutation , genetics , protein secondary structure , amino acid , gene , protein structure , mutation , genome , biochemistry , missense mutation
The hypothesis that synonymous codon usage is related to protein three‐dimensional structure is examined by investigating the correlation between synonymous codon usage and protein secondary structure. All except two codons in E. coli show the same secondary structural preference for alpha‐helix, beta‐strand or coil as that of amino acids to be encoded by the respective codons, while 17 codons show secondary structural bias in mammalian proteins. The results indicate that there is no significant correlation between synonymous codon usage and protein secondary structure in E. coli , but there is a correlation in mammals. It could be deduced that synonymous codons carry much less structural information in prokaryotes than in eukaryotes due to their divergent evolutionary mechanism.