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Stress‐induced expression of transcriptional repressor ICER in the adrenal gland
Author(s) -
Della Fazia Maria Agnese,
Servillo Giuseppe,
Foulkes Nicholas S,
Sassone-Corsi Paolo
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00944-2
Subject(s) - repressor , adrenal gland , endocrinology , adrenal cortex , medicine , anterior pituitary , biology , gene expression , pituitary gland , messenger rna , gene , transcriptional regulation , regulation of gene expression , hormone , microbiology and biotechnology , genetics
Second messenger cyclic AMP plays a central role in signalling within the hypothalamo‐pituitary‐adrenal (HPA) axis. Changes in gene expression are central to long‐term adaptations made in response to stress in the adrenal gland. Here we demonstrate that expression of the cAMP inducible transcriptional repressor, ICER (Inducible cAMP Early Repressor), is rapidly and powerfully induced in response to surgical stress in the rat adrenal gland. Hypophysectomisation blocks stress‐induced ICER expression. Finally we demonstrate that injection of the pituitary hormone ACTH (Adrenocorticotropin Hormone) induces robust ICER expression in the adrenal cortex. Thus, induction of the transcriptional repressor ICER is coupled to the HPA axis response to stress.