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Complex regulation of multiple cytohesin‐like genes in murine tissues and cells
Author(s) -
Kim Heui-Soo,
Chen Yali,
Lonai Peter
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00937-5
Subject(s) - complementary dna , biology , gene , cdna library , gene expression , microbiology and biotechnology , blot , northern blot , genetics
Three cytohesin‐like cDNA molecules were isolated from murine ES cell derived embryoid bodies. The genomic structure of one of the three, CLM2, has been determined and transcriptional variants of each were isolated from a mouse brain cDNA library. The relative expression patterns of CLM1, 2, 3 and their transcriptional alternatives were determined by RT‐PCR, nucleotide sequencing and RNA blotting. Their broad distribution and cell and tissue specific expression patterns suggest complex regulation during development and in the adult.