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Free fatty acids regulate the uncoupling protein and alternative oxidase activities in plant mitochondria
Author(s) -
Sluse Francis E.,
Almeida Andréa M.,
Jarmuszkiewicz Wieslawa,
Vercesi Anibal E.
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00922-3
Subject(s) - alternative oxidase , uncoupling protein , linoleic acid , mitochondrion , biochemistry , oxidase test , respiration , enzyme , chemistry , fatty acid , biology , botany , brown adipose tissue , adipose tissue
Two energy‐dissipating systems, an alternative oxidase and an uncoupling protein, are known to exist in plant mitochondria. In tomato fruit mitochondria linoleic acid, a substrate for the uncoupling protein, inhibited the alternative oxidase‐sustained respiration and decreased the ADP/O ratio to the same value regardless of the level of alternative oxidase activity. Experiments with varying concentrations of linoleic acid have shown that inhibition of the alternative oxidase is more sensitive to the linoleic acid concentration than the uncoupling protein activation. It can be proposed that these dissipating systems work sequentially during the life of the plant cell, since a high level of free fatty acid‐induced uncoupling protein activity excludes alternative oxidase activity.