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Macrophage populations of different origins have distinct susceptibilities to lipid peroxidation induced by β‐haematin (malaria pigment)
Author(s) -
Omodeo-Salè Fausta,
Basilico Nicoletta,
Folini Marco,
Olliaro Piero,
Taramelli Donatella
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00915-6
Subject(s) - pigment , lipid peroxidation , malaria , macrophage , hemozoin , chemistry , biochemistry , biology , plasmodium falciparum , immunology , oxidative stress , in vitro , organic chemistry
We investigated the susceptibility of peritoneal mouse macrophages and macrophage and microglia cell lines to the peroxidative activity of β‐haematin, the synthetic polymer identical to native malaria pigment. The extent of lipid peroxidation, measured as production of thiobarbituric acid reactive substances (TBARS), was greater for peritoneal macrophages than for cell lines and microglia cells. TBARS production apparently was not attributable to the release of free iron from the protoporphyrin moiety, but related to lower glutathione content and different lipid composition of the cell membrane. These findings offer a new interpretation for the contentious immunomodulatory effects of β‐haematin reported for phagocytes of different origins.