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Association of extracellular‐superoxide dismutase phenotype with the endothelial constitutive nitric oxide synthase polymorphism
Author(s) -
Adachi Tetsuo,
Li Wang Xing
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00903-x
Subject(s) - superoxide dismutase , phenotype , nitric oxide synthase , nitric oxide , allele , extracellular , polymorphism (computer science) , biology , genetics , intron , medicine , endocrinology , microbiology and biotechnology , gene , oxidative stress
The distribution of extracellular‐superoxide dismutase (EC‐SOD) levels in healthy Australian subjects was consistent with two distinct phenotypes in which the smaller group of subjects (3.3%) had 15‐fold higher levels. The EC‐SOD levels in individuals homozygous for endothelial constitutive nitric oxide synthase 4a (ecNOS4a), a rare allele for ecNOS repeat polymorphism at intron 4, were significantly lower than those in ecNOS4A/a and ecNOS4A/A subjects. Furthermore, NO levels were negatively correlated with the EC‐SOD levels in common EC‐SOD phenotype subjects. Whilst the mechanism remains speculative, it is possible that there is a significant interaction between EC‐SOD and ecNOS, or that common factor(s), either genetic or environmental, influence both of them.