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Identification of a novel human homolog of the Drosophila dlg, P‐dlg, specifically expressed in the gland tissues and interacting with p55
Author(s) -
Nakamura Hideo,
Sudo Tamotsu,
Tsuiki Hiromasa,
Miyake Hideaki,
Morisaki Tetsuro,
Sasaki Ji-ichiro,
Masuko Norio,
Kochi Masato,
Ushio Yukitaka,
Saya Hideyuki
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00882-5
Subject(s) - biology , microbiology and biotechnology , cytoplasm , gene , cytoskeleton , membrane protein , subcellular localization , cell , genetics , membrane
We have identified a novel human homolog of the Drosophila dlg tumor suppressor gene, termed P‐dlg , which has been mapped at chromosome 10q23. Unlike other human dlg homologs, P‐dlg is expressed in placenta and various gland tissues but not in brain. The P‐dlg protein is localized at the plasma membrane and cytoplasm, and it is expressed in the gland epithelial cells in normal prostate tissue but not in prostate cancer cell lines. Furthermore, we identified interaction between P‐dlg and p55 palmitoylated membrane protein by yeast two‐hybrid screening. These findings suggest that P‐dlg forms a complex with p55 at the plasma membrane and plays roles in maintaining the structure of epithelial cells and transmitting extracellular signals to the membrane and cytoskeleton, which may negatively regulate cell proliferation.