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Src phosphorylates EAST, a novel EGF receptor‐associated protein
Author(s) -
Lohi Olli,
Lehto Veli-Pekka
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00874-6
Subject(s) - endocytic cycle , proto oncogene tyrosine protein kinase src , endocytosis , phosphorylation , receptor , microbiology and biotechnology , sh3 domain , chemistry , biology , biochemistry
We have recently found and characterized EAST, a novel EGF receptor‐associated protein with SH3 and TAM domains. In this study we show that EAST becomes phosphorylated by Src kinase. This, in conjunction with our earlier observations on the close association between EAST and the endocytic machinery, suggests that EAST could be involved in Src‐dependent effects on EGF receptor endocytosis.