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Lipophilin, a novel heterodimeric protein of human tears
Author(s) -
Lehrer Robert I,
Xu Guorong,
Abduragimov Adil,
Dinh Nhu Nguyen,
Qu Xiao-Dan,
Martin Daniel,
Glasgow Ben J
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00852-7
Subject(s) - uteroglobin , homologous chromosome , steroid , protein superfamily , chemistry , tears , microbiology and biotechnology , biology , biochemistry , immunology , gene , hormone
We identified a novel heterodimeric protein, lipophilin AC, in human tears. One of its components, lipophilin A (69 residues; mass, 7575.1; p I , 9.47) was homologous to the C1 and C2 components of prostatein (‘estramustine‐binding protein'), the major secreted protein of rat prostate. Human lipophilin C (77 residues; mass, 8854.1; p I , 4.94) was homologous to the rat prostatein C3 component and to human mammaglobin, a protein overexpressed in some mammary carcinomas. Tear lipophilins A and C expand the roster of human uteroglobin superfamily members and provide models for exploring these typically steroid‐regulated and steroid‐binding molecules.