Premium
Expression of the SOX10 gene during human development
Author(s) -
Bondurand Nadege,
Kobetz Alexandra,
Pingault Veronique,
Lemort Nicole,
Encha-Razavi Ferechte,
Couly Gerard,
Goerich Derk E,
Wegner Michael,
Abitbol Marc,
Goossens Michel
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00843-6
Subject(s) - sox10 , neural crest , northern blot , biology , in situ hybridization , gene , gene expression , central nervous system , transcription factor , regulation of gene expression , microbiology and biotechnology , genetics , neuroscience
SOX10, a new member of the SOX gene family, is a transcription factor defective in the Dom ( Dominant megacolon ) mouse and in the human Shah‐Waardenburg syndrome. To help unravel its physiological role during human development, we studied SOX10 gene expression in embryonic, fetal, and adult human tissues by Northern blot and in situ hybridization. As in mice, the human SOX10 gene was essentially expressed in the neural crest derivatives that contribute to the formation of the peripheral nervous system, and in the adult central nervous system. Nevertheless, it was more widely expressed in humans than in rodents. The spatial and temporal pattern of SOX10 expression supports an important function in neural crest development.