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Proadrenomedullin N‐terminal 20 peptide (PAMP) stimulates aldosterone secretion by the intact rat adrenal glomerulosa by a cAMP‐dependent mechanism
Author(s) -
Thomson L.M.,
Kapas S.,
Hinson J.P.
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00828-x
Subject(s) - zona glomerulosa , aldosterone , secretion , endocrinology , medicine , steroid 11 beta hydroxylase , adrenal gland , mineralocorticoid , chemistry , protein kinase a , biology , steroid , angiotensin ii , kinase , biochemistry , hormone , blood pressure
Preproadrenomedullin, the precursor of proadrenomedullin N‐terminal 20 peptide (PAMP), is produced by rat zona glomerulosa cells. The actions of PAMP on the rat adrenal have been investigated. PAMP was found to stimulate aldosterone secretion and cAMP release by intact capsules, in a dose‐dependent manner, but had only a minor effect on dispersed cells. The effects of PAMP on aldosterone secretion were inhibited by HA1004, an inhibitor of protein kinase A. The difference between tissue preparations does not appear to be due to the actions of PAMP on local release of catecholamines as PAMP inhibited the release of catecholamines from rat capsular preparations. These data suggest that PAMP is a novel zona glomerulosa stimulant in intact capsular tissue, acting through cAMP.