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3‐Aminobenzamide inhibition of protein kinase C at a cellular level
Author(s) -
Ricciarelli Roberta,
Palomba Letizia,
Cantoni Orazio,
Azzi Angelo
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00811-4
Subject(s) - poly adp ribose polymerase , protein kinase a , polymerase , enzyme , chemistry , kinase , cyclin dependent kinase 9 , microbiology and biotechnology , mitogen activated protein kinase kinase , biochemistry , biology
3‐Aminobenzamide, a known inhibitor of poly‐(ADP‐ribose)‐polymerase has been found in the cell line U‐937 to inhibit protein kinase C at the same concentration as poly‐(ADP‐ribose)‐polymerase. 3‐Aminobenzamide was not able, however, to inhibit the isolated enzyme. An indirect mechanism of protein kinase C inhibition is proposed.