Premium
Negative regulation of the anti‐human immunodeficiency virus and chemotactic activity of human stromal cell‐derived factor 1α by CD26/dipeptidyl peptidase IV
Author(s) -
Ohtsuki Takashi,
Hosono Osamu,
Kobayashi Hiroshi,
Munakata Yasuhiko,
Souta Akiko,
Shioda Tatsuo,
Morimoto Chikao
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00763-7
Subject(s) - dipeptidyl peptidase , dipeptidyl peptidase 4 , stromal cell , chemokine , chemotaxis , recombinant dna , in vivo , biology , cell , chemistry , microbiology and biotechnology , immunology , inflammation , enzyme , biochemistry , cancer research , receptor , endocrinology , gene , type 2 diabetes , diabetes mellitus
Stromal cell‐derived factor 1α (SDF‐1α) is a chemokine that has been shown to prevent infection of T‐tropic HIV strains and is a possible substrate of CD26/dipeptidyl peptidase IV (DPPIV). In this study, we show that SDF‐1α was cleaved at the N‐terminal region by CD26/DPPIV and as a result the inhibitory activity of SDF‐1α against HIV infection disappeared. Moreover, the chemotactic activity of SDF‐1α also disappeared specifically by DPPIV activity of recombinant soluble CD26. These results suggested that dissemination of T‐tropic HIV strains in vivo may be facilitated by CD26/DPPIV via inactivation of functional SDF‐1α.