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Increased caveolin‐3 levels in mdx mouse muscles
Author(s) -
Vaghy Pal L.,
Fang Jin,
Wu Wenrong,
P. Vaghy Laszlo
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00738-8
Subject(s) - caveolae , duchenne muscular dystrophy , caveolin 3 , muscular dystrophy , caveolin 1 , mdx mouse , regeneration (biology) , biology , caveolin , endocrinology , microbiology and biotechnology , medicine , skeletal muscle , nitric oxide synthase , nitric oxide , anatomy , chemistry , dystrophin , signal transduction , genetics
The density of skeletal muscle caveolae is increased in Duchenne muscular dystrophy and its genetic homologue, the mdx mouse. This structural change is significant as it may indicate muscle regeneration. We identified in mdx mouse tibialis anterior muscles significantly increased levels of caveolin‐3, the chief protein in muscle caveolae, and reduced levels of neuronal nitric oxide synthase, an enzyme regulated by caveolin‐3. Similar changes occurred in the corresponding mRNA levels. These data suggest that induction of caveolin‐3 occurs and this may at least partly be responsible for increased number of caveolae, altered nNOS‐caveolin cycle, and regeneration of dystrophic muscles.