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Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide‐induced apoptosis
Author(s) -
Degli Esposti Mauro,
McLennan Holly
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00688-7
Subject(s) - ceramide , reactive oxygen species , apoptosis , mitochondrion , hydrogen peroxide , microbiology and biotechnology , anaerobic exercise , programmed cell death , oxygen , chemistry , biology , biochemistry , physiology , organic chemistry
Observations of apoptosis in virtual anaerobiosis have raised doubts on the significance of reactive oxygen species in the cascade of events of programmed cell death. This work presents evidence that cells and mitochondrial preparations produce similar levels of hydrogen peroxide under either aerobic or virtually anaerobic conditions. These levels are relevant to the increased production of radicals induced by a ceramide analog that promotes apoptosis. This ceramide acts at center o of mitochondrial complex III.