Premium
Characterization of a mammalian cDNA encoding a protein with high sequence similarity to the Drosophila regulatory protein Rhomboid
Author(s) -
Pascall John C.,
Brown Kenneth D.
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00622-x
Subject(s) - rhomboid , complementary dna , sequence (biology) , biology , protein sequencing , peptide sequence , computational biology , genetics , structural similarity , drosophila melanogaster , drosophila (subgenus) , similarity (geometry) , sequence alignment , gene , biochemistry , computer science , enzyme , proteases , artificial intelligence , image (mathematics)
The Drosophila regulatory protein Rhomboid has been demonstrated genetically to facilitate signalling within the Spitz/epidermal growth factor receptor/mitogen‐activated protein kinase pathway. Using a polymerase chain reaction (PCR)‐based strategy, we have cloned a human cDNA which encodes a protein that has high sequence similarity to Rhomboid. The encoded protein, termed rhomboid‐related protein (RRP), is predicted to contain seven transmembrane domains. Northern analysis indicates that RRP mRNA is expressed at highest levels in brain and kidney.