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The neurotransmitter role of diadenosine polyphosphates
Author(s) -
Miras-Portugal M.Teresa,
Gualix Javier,
Pintor Jesús
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00560-2
Subject(s) - ionotropic effect , metabotropic receptor , p2y receptor , receptor , biochemistry , chemistry , cytosol , extracellular , phosphatase , microbiology and biotechnology , purinergic receptor , biology , glutamate receptor , phosphorylation , enzyme
Diadenosine polyphosphates present at the cytosol can be transported to secretory granules allowing their exocytotic release. Extracellularly, they can act through specific metabotropic or ionotropic receptors, or as analogues of P2X and P2Y nucleotide receptors. The specific ionotropic receptor P4 is present in synaptic terminals, and modulated by protein kinases (PK) A and C and protein phosphatases. Activation of PKA or PKC, directly or through membrane receptors, results in a decrease of affinity or in reduction of the Ca 2+ transient respectively. Adenosine and ATP, both products of the extracellular destruction of diadenosine polyphosphates, acting through A 1 or P2Y receptors respectively, are important physiological modulators at the P4 receptor.