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Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells
Author(s) -
Kennedy Christopher H,
Cueto Rafael,
Belinsky Steven A,
Lechner John F,
Pryor William A
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00505-5
Subject(s) - oxidative stress , lung cancer , biology , cancer research , cancer , gene expression , genome instability , messenger rna , gene , cancer cell , microbiology and biotechnology , dna damage , biochemistry , medicine , genetics , dna
Human MutT homologue ( hMTH1 ) mRNA was overexpressed in SV‐40‐transformed non‐tumorigenic human bronchial epithelial cells (BEAS‐2B cells) and in 11 out of 12 human lung cancer cell lines relative to normal human bronchial epithelial cells. Expression levels of hMTH1 mRNA were inversely proportional to cellular levels of 8‐oxo‐deoxyguanosine. Together, these results suggest that hMTH1 gene expression may represent a molecular marker of oxidative stress that could ultimately be used to elucidate the temporal relationships between oxidative stress, genomic instability and the development of lung cancer.