Premium
A novel system of peptidergic regulation
Author(s) -
Karelin Andrei A,
Blishchenko Elena Yu,
Ivanov Vadim T
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00486-4
Subject(s) - paracrine signalling , peptide , microbiology and biotechnology , biology , endocrine system , biochemistry , chemistry , receptor , hormone
Systematic analysis of structure and biological activity of peptide components of tissue extracts and biological fluids allows us to formulate a novel concept of a peptidergic regulatory system, complementary to the conventional regulatory systems (i.e. nervous, endocrine and paracrine systems). According to that concept, the proteolytic degradation of tissue proteins carried out by a specific and regulated system of tissue‐specific enzymes and protein substrates gives rise to a large group of peptides, which we define as tissue‐specific peptide pool. As a result, functional proteins provide their proteolytically derived fragments for maintaining tissue homeostasis.