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Human RanBP3, a group of nuclear RanGTP binding proteins 1
Author(s) -
Mueller Liz,
Cordes* Volker C,
Bischoff F.Ralf,
Ponstingl Herwig
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00459-1
Subject(s) - ran , nucleoporin , nuclear transport , nuclear pore , biology , nuclear protein , binding domain , microbiology and biotechnology , binding site , biochemistry , cell nucleus , cytoplasm , transcription factor , gene
A group of novel human Ran‐binding proteins, RanBP3, was identified using the yeast two‐hybrid system via Ran‐mediated interaction with the nucleotide exchange factor RCC1. Several open reading frames, representing putative alternatively spliced products, were established by cDNA cloning. Two of them, RanBP3‐a and RanBP3‐b, encode nuclear hydrophilic proteins of 499 and 562 amino acid residues. The sequences contain FXFG motifs, characteristic of a subgroup of nucleoporins, and a C‐terminal domain showing similarity to the Ran‐binding protein RanBP1. These proteins are localized in the nucleus, preferentially bind RanGTP and may be nuclear effectors of the Ran pathway.