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The CRH‐ACTH‐biogenic amine axis in invertebrate immunocytes activated by PDGF and TGF‐β
Author(s) -
Ottaviani Enzo,
Caselgrandi Eva,
Kletsas Dimitris
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00438-4
Subject(s) - platelet derived growth factor receptor , biogenic amine , transforming growth factor , growth factor , mytilus , endocrinology , medicine , hemolymph , hormone , norepinephrine , immune system , biology , chemistry , microbiology and biotechnology , dopamine , neurotransmitter , biochemistry , receptor , central nervous system , ecology , immunology
In immunocytes from the mollusc Mytilus galloprovincialis , the major pathway followed by platelet‐derived growth factor (PDGF)‐AB and transforming growth factor (TGF)‐β1 in provoking the release of norepinephrine, epinephrine and dopamine into cell‐free hemolymph (serum) is mediated by a corticotropin‐releasing hormone‐adrenocorticotropin hormone (CRH‐ACTH) biogenic amine axis. This axis not only annulled the inhibiting properties of PDGF‐AB, it even reversed the latter's effect, while the inducing effect of TGF‐β1 was amplified. These findings show that non‐classical immune‐neuroendocrine molecules, such as PDGF‐AB and TGF‐β1, are involved in building stress response, using the same conserved mechanisms present from invertebrates to vertebrates.