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Intragenic recombinations in rotaviruses
Author(s) -
Suzuki Yoshiyuki,
Gojobori Takashi,
Nakagomi Osamu
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00415-3
Subject(s) - recombination , rotavirus , serotype , biology , gene , virology , genetics , immune escape , immune system , virus
In this paper, evidence for intragenic recombination in the VP7 gene between rotavirus strains bearing different serotypes is demonstrated for the first time. Intragenic recombination may be one of the escaping mechanisms from the host immune system for rotavirus. This process involves exchanging antigenic regions, thus questioning the use of multivalent vaccines for the prevention of rotavirus infection.