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Somatic and germline clone analysis in mutants of the S ‐adenosylmethionine synthetase encoding gene in Drosophila melanogaster
Author(s) -
Larsson Jan,
Rasmuson-Lestander Åsa
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00408-6
Subject(s) - drosophila melanogaster , germline , biology , mutant , phenotype , somatic cell , imaginal disc , gene , genetics , drosophilidae , offspring , melanogaster , germline mutation , mutation , microbiology and biotechnology , pregnancy
We have analysed the phenotypic consequences of homozygous mutant clones in the S ‐adenosylmethionine synthetase encoding gene in Drosophila melanogaster . The results suggest that SamS function is required for cell proliferation/growth in embryonic/early larval cells and during development of imaginal disc cells. Homozygous SamS germline clones can, however, develop and give rise to viable heterozygous offspring. This offspring expresses a Minute ‐like phenotype. We suggest that this phenotype is caused by an obstruction of the polyamine biosynthesis.