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1,25‐Dihydroxyvitamin D 3 inhibits tenascin‐C expression in mammary epithelial cells
Author(s) -
González-Sancho José Manuel,
Alvarez-Dolado Manuel,
Muñoz Alberto
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00348-2
Subject(s) - microbiology and biotechnology , tenascin c , chemistry , expression (computer science) , biology , computer science , extracellular matrix , programming language
Tenascin‐C is an extracellular matrix protein with growth‐, invasion‐ and angiogenesis‐promoting activities. Tenascin‐C is upregulated in breast carcinoma and stromal cells, and in many other cell types during tumorigenesis. We demonstrate that tenascin‐C RNA expression is inhibited by 1,25‐dihydroxyvitamin D 3 (1,25‐D 3 ) in a variety of mouse and human mammary epithelial cell lines exhibiting normal or malignant phenotype. In EpH4 cells, the inhibition is maximum 24 h after 1,25‐D 3 treatment and correlates with a dose‐dependent reduction in the synthesis of tenascin‐C protein. Furthermore, 1,25‐D 3 also abolishes the induction of tenascin‐C by serum or the tumor promoter 12‐ O ‐tetradecanoyl phorbol 13‐acetate. The inhibition of tenascin‐C expression may be relevant for the anticancer activity of 1,25‐D 3 .