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Contribution of NO synthases to neutrophil infiltration in the gastric mucosal lesions in rats with water immersion restraint stress
Author(s) -
Nishida Keiji,
Ohta Yoshiji,
Ishiguro Isao
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00237-3
Subject(s) - myeloperoxidase , infiltration (hvac) , chemistry , gastric mucosa , nitric oxide synthase , medicine , enzyme assay , endocrinology , ulcer index , enzyme , inflammation , biochemistry , stomach , physics , thermodynamics
A decrease in constitutive NO synthase (cNOS) activity and an increase in inducible NO synthase (iNOS) activity occurred with an increase in myeloperoxidase (MPO) activity, an index of neutrophil infiltration, in the gastric mucosa of rats with water immersion restraint (WIR) stress. This increase in gastric mucosal MPO activity was enhanced by pretreatment with N G ‐monomethyl l ‐arginine, a non‐selective NOS inhibitor, but was prevented with maintenance of gastric mucosal cNOS activity by pretreatment with aminoguanidine, a selective iNOS inhibitor. The MPO activity was negatively correlated with the cNOS activity in all WIR‐stressed rats used ( r =−0.723). These results suggest that a decrease in cNOS activity could contribute to an increase in neutrophil infiltration in the gastric mucosa of WIR‐stressed rats.