Premium
Existence of four acetylcholinesterase genes in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae 1
Author(s) -
Grauso Marta,
Culetto Emmanuel,
Combes Didier,
Fedon Yann,
Toutant Jean-Pierre,
Arpagaus Martine
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00191-4
Subject(s) - caenorhabditis elegans , operon , genetics , gene , biology , caenorhabditis , nematode , escherichia coli , ecology
Three genes, ace‐1 , ace‐2 and ace‐3 , respectively located on chromosomes X, I and II, were reported to encode acetylcholinesterases (AChEs) of classes A, B and C in the nematode Caenorhabditis elegans . We have previously cloned and sequenced ace‐1 in the two related species C. elegans and C. briggsae . We report here partial sequences of ace‐2 (encoding class B) and of two other ace sequences located in close proximity on chromosome II in C. elegans and C. briggsae . These two sequences are provisionally named ace‐x and ace‐y , because it is not possible at the moment to establish which of these two genes corresponds to ace‐3 . Ace‐x and ace‐y are transcribed in vivo as shown by RT‐PCR and they are likely to be included in a single operon.