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TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling
Author(s) -
Pan Guohua,
Ni Jian,
Yu Guo-liang,
Wei Ying-Fei,
Dixit Vishva M
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00135-5
Subject(s) - receptor , microbiology and biotechnology , apoptosis , extracellular , intracellular , ectopic expression , tumor necrosis factor alpha , death domain , programmed cell death , biology , chemistry , cell culture , genetics , immunology
TRAIL/Apo‐2L induces rapid apoptosis of a variety of tumor cell lines. A family of tumor necrosis factor receptor‐related molecules have been identified as receptors for TRAIL. Herein, we report the identification of another member of the TRAIL receptor family, TRUNDD (TRAIL receptor with a truncated death domain). The TRUNDD transcript was detected in multiple human tissues. TRUNDD is highly homologous to all known TRAIL receptors and has an extracellular TRAIL‐binding domain but lacks a functional intracellular death domain and does not induce apoptosis. Consistent with an inhibitory role, ectopic expression of TRUNDD attenuated TRAIL‐induced apoptosis in mammalian cells.