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Do transmembrane protein superfolds exist?
Author(s) -
Jones David T
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00095-7
Subject(s) - transmembrane protein , transmembrane domain , membrane protein , network topology , globular protein , topology (electrical circuits) , biology , computational biology , computer science , mathematics , genetics , combinatorics , membrane , biochemistry , receptor , operating system
A reliable and widely used transmembrane protein structure prediction algorithm was applied to five representative genomic sequence data sets in order to re‐examine the hypothesis that in contrast to globular proteins there are no favored transmembrane protein fold families. When the number of predicted membrane spanning segments and the topology of these segments is taken into account then definite biases are observed which suggest that certain transmembrane topologies are significantly more common than others.