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African origin of GB virus C/hepatitis G virus 1
Author(s) -
Tanaka Yasuhito,
Mizokami Masashi,
Orito Etsuro,
Ohba Ken-ichi,
Kato Takanobu,
Kondo Yutaka,
Mboudjeka Innocent,
Zekeng Leopold,
Kaptue Lazare,
Bikandou Blaise,
M'Pele Pierre,
Takehisa Jun,
Hayami Masanori,
Suzuki Yoshiyuki,
Gojobori Takashi
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00083-0
Subject(s) - gb virus c , virology , phylogenetic tree , biology , hepatitis a virus , virus , ns5a , hepatitis c virus , indel , flaviviridae , genetics , hepacivirus , gene , genotype , single nucleotide polymorphism
Ninety‐four GB virus C/hepatitis G virus (GBV‐C/HGV) RNA‐positive serum samples were obtained from all over the world. We found that all 15 GBV‐C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12‐amino acid indel (i.e. insertion or deletion) in the non‐structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV‐A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBV‐C/HGV.