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The effect of activin and FSH on the differentiation of rat granulosa cells
Author(s) -
Kishi Hiroshi,
Minegishi Takashi,
Tano Mari,
Kameda Takashi,
Ibuki Yoshito,
Miyamoto Kaoru
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00023-4
Subject(s) - endocrinology , medicine , follicle stimulating hormone receptor , follicle stimulating hormone , granulosa cell , luteinizing hormone , gonadotropin , human chorionic gonadotropin , activin type 2 receptors , chemistry , biology , hormone , tgf beta signaling pathway , transforming growth factor
The differentiation of granulosa cells is regulated by follicle‐stimulating hormone (FSH) and local ovarian factors. To further analyze the role of FSH and activin in this process, we have examined the effect of FSH and activin on FSH and luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptor induction in granulosa cells. Granulosa cells from diethylstilbestrol (DES)‐primed immature rats produce activin and maintain FSH receptor without LH/hCG receptor expression in the absence of FSH. On the other hand, FSH induced granulosa cells to differentiate into more mature granulosa cells in which higher LH/hCG receptor expression and diminished activin production were observed.