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Expression and characterization of a dopamine D4R variant associated with delusional disorder
Author(s) -
Zenner Marie-Thérèse,
Nobile Maria,
Henningsen Robert,
Smeraldi Enrico,
Civelli Olivier,
Hartman Deborah S,
Catalano Marco
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01617-7
Subject(s) - delusional disorder , dopamine , schizophrenia (object oriented programming) , dopamine receptor , antipsychotic , psychology , genetics , medicine , psychosis , endocrinology , biology , neuroscience , psychiatry
Multiple genetic polymorphisms of the human dopamine D4 receptor (hD4R) have been identified including a 12 bp repeat in exon 1 associated with a psychotic condition called delusional disorder. Competition binding assays revealed minor pharmacological differences between the recombinant A1 (normal) and A2 (delusional) proteins with respect to quinpirole and the antipsychotic clozapine, however no functional differences were detected for receptor activation by dopamine, epinephrine, or norepinephrine. Our results suggest that this polymorphism may only confer susceptibility to delusional disorder in combination with other genetic or environmental factors.