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Crosstalk: phosphorylation of α 1b ‐adrenoceptors induced through activation of bradykinin B2 receptors
Author(s) -
Medina Luz del Carmen,
Vázquez-Prado José,
Torres-Padilla Marı́a Elena,
Mendoza-Mendoza Artemio,
Cruz-Muñoz Mario Ernesto,
Garcı́a-Sáinz J.Adolfo
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01615-3
Subject(s) - bradykinin , desensitization (medicine) , phosphorylation , bradykinin receptor , chemistry , receptor , kallidin , medicine , endocrinology , adrenergic receptor , crosstalk , intracellular , kinin , biophysics , biology , biochemistry , physics , optics
The possibility that bradykinin could modulate α 1b ‐adrenoceptors was studied. It was observed that bradykinin and kallidin increased α 1b ‐adrenoceptor phosphorylation and that such effect was also blocked by Hoe 140. Interestingly, the ability of norepinephrine to increase intracellular calcium concentration was not altered by pretreatment of the cells with bradykinin, i.e. bradykinin induced α 1b ‐adrenoceptor phosphorylation but this did not lead to receptor desensitization.