Premium
Human ϵ‐sarcoglycan is highly related to α‐sarcoglycan (adhalin), the limb girdle muscular dystrophy 2D gene 1
Author(s) -
McNally Elizabeth M,
Ly Chantal T,
Kunkel Louis M
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01593-7
Subject(s) - muscular dystrophy , biology , genetics , limb girdle muscular dystrophy , exon , gene , intron , microbiology and biotechnology , mutation
The dystrophin‐glycoprotein complex (DGC) is critical for muscle membrane stability. The sarcoglycans are transmembrane proteins within the DGC, and the function of the sarcoglycans is unknown. Mutations in sarcoglycan genes cause autosomal recessive muscular dystrophy. We have identified a new sarcoglycan gene with high homology to α‐sarcoglycan highlighting the redundancy of the DGC. This gene, named ϵ‐sarcoglycan, has an identical intron‐exon structure to α‐sarcoglycan, and is more broadly expressed. The characterization of ϵ‐sarcoglycan should make it possible to determine if it, like the other sarcoglycan genes, is mutated in muscular dystrophy.