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Periportal localization of glucagon receptor mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures
Author(s) -
Krones Anja,
Kietzmann Thomas,
Jungermann Kurt
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01556-1
Subject(s) - glucagon , hepatocyte , glucagon receptor , messenger rna , receptor , endocrinology , medicine , chemistry , microbiology and biotechnology , biology , biochemistry , gene , in vitro , hormone
Glucagon is the major hormone activating glycogenolysis and gluconeogenesis both localized in the periportal, more aerobic zone of the liver. Accordingly, the glucagon receptor (GcgR) mRNA was found to be predominantly expressed in this area. In hepatocyte cultures high glucose concentrations as reached after a meal induced GcgR mRNA under arterial but not venous pO 2 . The induction by glucose was partially antagonized by insulin and unaffected by glucagon. The modulation by O 2 of the glucose‐dependent induction would contribute to the zonated expression of GcgR mRNA.