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Yeast gene YOR137c is involved in the activation of the yeast plasma membrane H + ‐ATPase by glucose
Author(s) -
de la Fuente Natalia,
Maldonado Ana M,
Portillo Francisco
Publication year - 1997
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(97)01478-6
Subject(s) - yeast , chemistry , saccharomyces cerevisiae , membrane , atpase , biochemistry , microbiology and biotechnology , biology , enzyme
Glucose triggers transcriptional and post‐transcriptional mechanisms that increase the level and activity of Saccharomyces cerevisiae plasma membrane H + ‐ATPase. We have studied the post‐transcriptional activation of the enzyme by glucose and have found that the YOR137c gene product is implicated in this activation. Deletion of YOR137c does not affect the level of Pma1 at the plasma membrane, but disturbs the glucose‐triggered V max increase of the enzyme. We propose that at least two independent mechanisms are involved in glucose activation of the H + ‐ATPase.